(A) What is the optimal length of administration for antibiotic treatment following resection arthroplasty? (B) What is the optimal mode of administration for antibiotic treatment following resection arthroplasty?

Authors: Scott R. Nodzo, Oscar Murillo, Anne Lachiewicz, Keely Boyle, Michael O’Callaghan
RECOMMENDATION: Antimicrobial therapy should be individualized and based on the sensitivity profi le of the microorganism, patient tolerance and drug side-eff ect profi le. There is no conclusive evidence supporting the exact length of antibiotic therapy after resection arthroplasty. We recommend treatment for two to six weeks. Either intravenous, oral antibiotics, or a combination are acceptable for treatment
following resection arthroplasty as long as the oral agent has adequate bioavailability and can achieve a concentration at the site of infection to eradicate the infecting organism, if used alone.
LEVEL OF EVIDENCE: Moderate
DELEGATE VOTE: Agree: 87%, Disagree: 9%, Abstain: 4% (Super Majority, Strong Consensus)

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