Are there any genetic factors that predispose patients to surgical site infection/periprosthetic joint infection (SSI/PJI) or predict the success of the treatment for SSI/PJI?

Are there any genetic factors that predispose patients to surgical site infection/periprosthetic joint infection (SSI/PJI) or predict the success of the treatment for SSI/PJI?

Authors: Christopher E. Pelt, Li Cao, Lidong Wu, Laura Certain, Michael B. Anderson, Jeremy M. Gililland

RECOMMENDATION: The evidence suggests a potential heritable predisposition is possible, but there is a lack of definitive evidence supporting specific genetic risk factors for SSI/PJI after total joint arthroplasty (TJA).

LEVEL OF EVIDENCE: Limited

DELEGATE VOTE: Agree: 93%, Disagree: 2%, Abstain: 5% (Super Majority, Strong Consensus)

RATIONALE

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