Are there any tests that can guide antimicrobial treatment in patients with periprostetic joint infections (PJIs) so as to determine when treatment may be discontinued?

Are there any tests that can guide antimicrobial treatment in patients with periprostetic joint infections (PJIs) so as to determine when treatment may be discontinued?

Authors: Angela Hewlett, Isabel Ramirez

RECOMMENDATION: No. There are no tests that can be used to guide therapies and monitor responses to treatments in patients with PJIs. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are considered useful for monitoring responses to treatments; however, sustained elevations after treatment does not predict persistent infections. Emerging biomarkers, such as D-dimer and presepsin, have shown promising results. Nevertheless, more studies are required to assess their role in monitoring response to treatment in patients with PJIs.

LEVEL OF EVIDENCE: Moderate

DELEGATE VOTE: Agree: 89%, Disagree: 8%, Abstain: 3% (Super Majority, Strong Consensus)

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