Authors: Edward Schwarz, Jamie Esteban, Hamidreza Yazdi, John-Jairo Aguilera-Correa
RESPONSE: A mature bacterial biofilm has limited permeability to neutrophils and macrophages. Those that get through are clinically ineffective at eradicating biofilm bacteria. While neutrophils and macrophages are capable of engulfing and killing planktonic bacteria, they are not innately capable of effectively engulfing and killing sessile bacteria in biofilm.
LEVEL OF EVIDENCE: Strong
DELEGATE VOTE: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)