Can a biomaterial surface be modified to dispel bacterial adherence and biofilms? What are the potential concerns in modifying implant surfaces to combat biofilms?

Authors: Yixin Zhou, Matthew Kheir, Valentia Antoci, Luigi Zagra

RESPONSE: The purpose of the surface modification is to decrease perioperative bacterial adherence and thus prevent biofilm formation. This has been shown in vitro studies and in vivo animal models. There have been numerous strategies devised to alter surfaces. Such modified surfaces may interfere with the expected osseointegration, mechanical stability, and long-term implant survivability. The duration of long-term
anti-infective effects are unknown. To date, no positive in vitro effect has been translated into a clinical setting.

LEVEL OF EVIDENCE: Consensus

DELEGATE VOTE: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)

PRE-MEETING RATIONALE

B10