Is one dose of preoperative antibiotic adequate for patients undergoing total joint arthroplasty (TJA)?

Authors: Timothy L. Tan, Wei Huang, Thorsten Seyler

RECOMMENDATION: Despite the current guidelines from the Centers for Disease Control and Prevention (CDC) advocating for a single dose of perioperative antibiotics, these studies are underpowered and primarily in specialties outside orthopaedics. From the limited evidence available,
it appears that a single perioperative dose of antibiotics, compared to multiple doses, does not increase the rate of subsequent surgical site infections/ periprosthetic joint infections (SSIs/PJIs). A randomized prospective study in patients undergoing elective arthroplasty is underway that
should answer this question defi nitively.

LEVEL OF EVIDENCE: Limited

DELEGATE VOTE: Agree: 92%, Disagree: 7%, Abstain: 3% (Super Majority, Strong Consensus)

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