Is synovial fluid or fracture hematoma always aseptic? If not, could this play a role in acute infection or periprosthetic joint infection (PJI) after open reduction and internal fixation (ORIF)?

Authors: Mitch Harris, Abhiram R. Bhashyam, Andre Shaffer

RECOMMENDATION: Fracture hematoma is not always aseptic. It is unknown if synovial fluid is always aseptic. In addition, it is unclear if this plays a role in acute infection or fracture-related infection (FRI) after ORIF.

LEVEL OF EVIDENCE: Moderate

DELEGATE VOTE: Agree: 95%, Disagree: 5%, Abstain: 0% (Unanimous, Strongest Consensus)

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