Is there a role for (a) synovial or (b) serum IL-6 in the diagnosis of shoulder periprosthetic joint infection (PJI)?

Authors: Joseph Iannoti, Victor Naula, Eric Ricchett i
RECOMMENDATION: (a) There is a potential role for synovial fl uid IL-6 in the diagnosis of shoulder PJI, both as an individual marker and when interpreted in combination with other synovial fl uid markers. (b) Although its specifi city is high, serum IL-6 does not appear to provide additional information beyond the more readily available serum markers (erythrocyte sedimentation rate (ESR), C-reative protein (CRP), white blood cell (WBC) count).
LEVEL OF EVIDENCE: Moderate
DELEGATE VOTE: Agree: 92%, Disagree: 0%, Abstain: 8% (Super Majority, Strong Consensus)

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