Is there a role for administration of prolonged oral antibiotics following primary total joint arthroplasty (TJA)?

Authors: Massimo Franceschini, Rafael Franco-Cendejas, Massimo Coen, Federico Calabrò
RECOMMENDATION: No. The administration of prolonged oral antibiotics in the context of perioperative prophylaxis after primary TJA is not recommended. Continuing antibiotic prophylaxis longer than 24 hours after wound closure has not proven to be beneficial; indeed, it may contribute to the development of antimicrobial resistance, carries risks and adds to healthcare costs.
LEVEL OF EVIDENCE: Moderate
DELEGATE VOTE: Agree: 95%, Disagree: 4%, Abstain: 1% (Unanimous, Strongest Consensus)

hk146