Is there a role for percutaneous bone sampling (biopsy) for microbiological diagnosis of septic arthritis/osteomyelitis (OM)? If so, when should this be performed?

Authors: Muhammad Amin Chinoy, Sher Wali Khan

RECOMMENDATION: Yes. Percutaneous bone sampling (biopsy) is very safe and cost-effective and can be obtained from any site under the guidance of fluoroscopy or computed tomography (CT). It has a low sensitivity for microbiological diagnosis of OM that can be enhanced by the addition of histopathological examination. Literature suggests that bone sampling should be performed before initiating empirical antibiotic therapy.

LEVEL OF EVIDENCE: Limited

DELEGATE VOTE: Agree: 88%, Disagree: 7%, Abstain: 5% (Super Majority, Strong Consensus)

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