Is there evidence that interference with bacterial communication by blocking quorum sensing molecules can minimize biofilm formation in vivo?

Is there evidence that interference with bacterial communication by blocking quorum sensing molecules can minimize biofilm formation in vivo?

Authors: Alex McLaren, Garth D. Ehrlich

RESPONSE: In vivo animal studies have demonstrated that interference with quorum sensing signals/molecules in some infections leads to decreased biofilm formation. There are contradictory results in Staphylococcus species. However, there are no clinical studies demonstrating this phenomenon.

LEVEL OF EVIDENCE: Limited

DELEGATE VOTE: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)

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