Is there evidence that interference with bacterial communication by blocking quorum sensing molecules can minimize biofilm formation in vivo?

Authors: Alex McLaren, Garth D. Ehrlich

RESPONSE: In vivo animal studies have demonstrated that interference with quorum sensing signals/molecules in some infections leads to decreased biofilm formation. There are contradictory results in Staphylococcus species. However, there are no clinical studies demonstrating this phenomenon.

LEVEL OF EVIDENCE: Limited

DELEGATE VOTE: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)

PRE-MEETING RATIONALE

B9