Should operative treatment differ in patients with systemic sepsis in the setting of periprosthetic joint infection (PJI)?

Authors: Antony Rapisarda, Tae-Kyun Kim, Salvador Rivero-Boschert

RECOMMENDATION: Yes. Patients with systemic sepsis in the setting of PJI should have surgical bioburden reduction, either with implant retention or resection of components (if indicated and safe), along with concurrent anti-microbial therapy. Reimplantation should be delayed until sepsis is resolved.

LEVEL OF EVIDENCE: Limited

DELEGATE VOTE: Agree: 79%, Disagree: 19%, Abstain: 2% (Super Majority, Strong Consensus)