What antibiotic therapy (agent, route, dose and duration) is recommended for gram-negative acute periprosthetic joint infections (PJIs) being treated with debridement, antibiotics and implant retention (DAIR)?

What antibiotic therapy (agent, route, dose and duration) is recommended for gram-negative acute periprosthetic joint infections (PJIs) being treated with debridement, antibiotics and implant retention (DAIR)?

Authors: Jean Yombi, Marjan Wouthuyzen-Bakker

RECOMMENDATION: Following surgical intervention (DAIR), gram-negative acute PJI patients should also receive antibiotic treatment for 6 to 12 weeks based on the type of organism. In fluoroquinolone-susceptible cases, the recommended antibiotic agent is a fluoroquinolone.

LEVEL OF EVIDENCE: Moderate

DELEGATE VOTE: Agree: 83%, Disagree: 11%, Abstain: 6% (Super Majority, Strong Consensus)

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