What is the diagnostic accuracy and threshold of D-dimer in the diagnosis of periprosthetic joint infections (PJIs)?

Authors: Majd Tarabichi, AliSina Shahi
RECOMMENDATION: Recent literature supports the use of D-dimer as a serological marker for the diagnosis of PJIs. D-dimer has been shown to best perform at a threshold of 850 ng/mL. However, this threshold was determined internally from a cohort in a single institution study. Further studies are needed in order to validate this threshold or establish a more rigorous threshold.
LEVEL OF EVIDENCE: Limited
DELEGATE VOTE: Agree: 74%, Disagree: 16%, Abstain: 10% (Super Majority, Strong Consensus)

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