What is the most appropriate perioperative prophylactic antibiotic (agent, route and number of doses) for patients undergoing primary total joint arthroplasty (TJA) to reduce the risk of subsequent surgical site infections/periprosthetic joint infections (SSIs/PJIs)?

Authors: Francisco Reyes, Arthur Malkani, Francisco Casas, Daniel Cuellar

RECOMMENDATION: The most appropriate perioperative prophylactic antibiotic is a fi rst or second-generation cephalosporin (i.e., cefazolin or
cefuroxime) administered intravenously within 30 to 60 minutes prior to incision as a single- and weight-adjusted dose.

LEVEL OF EVIDENCE: Strong

DELEGATE VOTE: Agree: 90%, Disagree: 8%, Abstain: 2% (Super Majority, Strong Consensus)

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