What is the most effective combination of antibiotics in the treatment of acute periprosthetic joint infections (PJIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) that has undergone surgical management with debridement, antibiotics and implant retention (DAIR)?

Authors: Camelia Marculescu, Silvano Esposito
RECOMMENDATION: We recommend a combination of a parenteral antibiotic plus oral rifampin for one to six weeks, followed by rifampin and a companion highly bioavailable oral drug for additional three months, depending on the susceptibility profi le of MRSA, patient tolerability and side eff ect profi le.
LEVEL OF EVIDENCE: Limited
DELEGATE VOTE: Agree: 88%, Disagree: 10%, Abstain: 2% (Super Majority, Strong Consensus)

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