What is the most effective combination of antibiotics in the treatment of acute periprosthetic joint infections (PJIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) that has undergone surgical management with debridement, antibiotics and implant retention (DAIR)?

What is the most effective combination of antibiotics in the treatment of acute periprosthetic joint infections (PJIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) that has undergone surgical management with debridement, antibiotics and implant retention (DAIR)?

Authors: Camelia Marculescu, Silvano Esposito

RECOMMENDATION: We recommend a combination of a parenteral antibiotic plus oral rifampin for one to six weeks, followed by rifampin and a companion highly bioavailable oral drug for additional three months, depending on the susceptibility profile of MRSA, patient tolerability and side effect profile.

LEVEL OF EVIDENCE: Limited

DELEGATE VOTE: Agree: 88%, Disagree: 10%, Abstain: 2% (Super Majority, Strong Consensus)

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