What is the most optimal prophylaxtic antibiotic coverage and treatment duration for open fractures of long bones?

What is the most optimal prophylaxtic antibiotic coverage and treatment duration for open fractures of long bones?

Authors: Willem-Jan Metsemakers, Charalampos Zalavras

RECOMMENDATION: The use of prophylactic antibiotics for open fractures of long bones has a protective effect against early infection. Antibiotics should be administered as soon as possible after the injury. The antibiotic of choice should target gram-positive organisms. Additional coverage for gram-negative organisms should be considered for patients with high-energy open fractures. Antibiotics should not be continued for more than 72 hours after wound closure.

LEVEL OF EVIDENCE: • Efficacy of prophylactic antibiotics – Strong • Timing of prophylactic antibiotics – Moderate • Choice of antibiotics – Limited • Treatment duration – Moderate

DELEGATE VOTE: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)

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