What is the optimal antibiotic therapy in cases of culture-negative (CN) periprosthetic joint infections (PJIs)?

Authors: Harriet Hughes, Gina Ann Suh, Ruben Anemüller, Christian Lausmann

RECOMMENDATION: In patients with true CN PJIs, the antibiotics should be selected to have broad spectrum activity against both gram-positive and gram-negative organisms. In addition, the exact choice should relate to the known modern epidemiology in that country.

LEVEL OF EVIDENCE: Limited

DELEGATE VOTE: Agree: 87%, Disagree: 6%, Abstain: 7% (Super Majority, Strong Consensus)