What is the relevance of minimum inhibitory concentration (MIC) of infecting organisms in biofilm-mediated chronic infection?

Authors: Jeppe Lange, Matthew Scarborough, Robert Townsend

RESPONSE: The use of MIC is limited to (1) defining antibiotics that the microorganism is susceptible to in its planktonic state but cannot be used to guide treatment of biofilm-based bacteria and (2) selecting long-term suppressive antibiotic regimens where eradication of infection is not anticipated. Alternative measures of antibiotic efficacy specifically in the context of biofilm-associated infection should be developed and
validated.

LEVEL OF EVIDENCE: Strong

DELEGATE VOTE: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)

PRE-MEETING RATIONALE

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