What is the role of host gene expression and severity of acute osteoarticular infection in children, especially methicillin-resistant Staphylococcus aureus (S. aureus), or MRSA, infection?

Authors: Ali Parsa, Irene Kalbian

RECOMMENDATION: Unknown. The limited literature available suggests altered host gene transcription related to the balance of the body’s adaptive and innate immune responses may increase pediatric patients’ susceptibility to severe osteoarticular infection, particularly in cases of MRSA. However, much more investigation is needed to determine which genes are most useful and how they can be utilized to help physicians anticipate the course of infection in a given patient.

LEVEL OF EVIDENCE: Consensus

DELEGATE VOTE: Agree: 75%, Disagree: 3%, Abstain: 22% (Super Majority, Strong Consensus)

Peds-16