What is the role of the microbial synergy in polymicrobial infections?

Authors: Igor Shubnyakov, Guillermo A. Bonilla León, Timothy L. Tan, Vanya Gant

Question:  What is the role of the microbial synergy in polymicrobial infections?

Response: In polymicrobial infections, a complex environment may be formed in which microbiological interactions exist between microorganisms. Scientific evidence exists to show that combinations of bacterial species may exist whereby these can protect each other from antibiotic action via the exchange of virulence and antibiotic resistance genes, and this may be evident in adverse outcomes for polymicrobial orthopaedic implant-related infections. It is also probable that polymicrobial infections may be more likely in patients with poor immunity and tissue healing.

Level of evidence: Strong

Delegate vote: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)

Rationale:

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