What prophylactic antibiotic (type, dose and route of administration) should be administered perioperatively for patients undergoing total ankle arthroplasty (TAA)?

What prophylactic antibiotic (type, dose and route of administration) should be administered perioperatively for patients undergoing total ankle arthroplasty (TAA)?

Authors: Marisa Sanchez, Cecilia Losada

RECOMMENDATION: The administration of prophylactic antibiotics before TAA potentially reduces the incidence of surgical site infection (SSI) and/or periprosthetic joint infection (PJI). Weight-based (of at least 2 gm) Cefazolin administered intravenously within 60 minutes prior to the procedure can be an adequate choice for antibiotic prophylaxis. If the patient has a beta-lactam anaphylaxis, we recommend an appropriate alternative antibiotic effective against Staphylococcus. It is unclear whether prophylaxis should be given as a single dose or as multiple doses.

LEVEL OF EVIDENCE: Strong

DELEGATE VOTE: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)

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