What prophylactic antibiotic (type, dose and route of administration) should be administered perioperatively for patients undergoing total ankle arthroplasty (TAA)?

Authors: Marisa Sanchez, Cecilia Losada

RECOMMENDATION: The administration of prophylactic antibiotics before TAA potentially reduces the incidence of surgical site infection (SSI) and/or periprosthetic joint infection (PJI). Weight-based (of at least 2 gm) Cefazolin administered intravenously within 60 minutes prior to the procedure can be an adequate choice for antibiotic prophylaxis. If the patient has a beta-lactam anaphylaxis, we recommend an appropriate alternative antibiotic effective against Staphylococcus. It is unclear whether prophylaxis should be given as a single dose or as multiple doses.

LEVEL OF EVIDENCE: Strong

DELEGATE VOTE: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)