What should be the time delay between preoperative chemo/radiotherapy and a surgical tumor resection in order to minimize incidence of surgical site infection/ periprosthetic joint infection (SSI/PJI)?

What should be the time delay between preoperative chemo/radiotherapy and a surgical tumor resection in order to minimize incidence of surgical site infection/ periprosthetic joint infection (SSI/PJI)?

Authors: Germán Luis Farfalli, Peter Choong, Sam Francis

RECOMMENDATION: Unknown. There is no data that supports the best time delay between preoperative chemo/radiotherapy and a surgical tumor resection to minimize the incidence of SSI/PJI. There are multiple intrinsic factors of each patient that can determine the best time to implant an endoprosthesis after a neoadjuvant treatment. Although no significance was seen between preoperative radiotherapy and surgical timing on wound complications (WC), trends suggest rates are lower if surgery is performed between 3 and 6 weeks following radiotherapy.

LEVEL OF EVIDENCE: Consensus

DELEGATE VOTE: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)

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