When is the optimal time to change intravenous (IV) antibiotic(s) to an oral agent(s) after a resection arthroplasty as part of two-stage exchange?

Authors: José Cordero-Ampuero, Marc Nijhof, Katherine Belden
RECOMMENDATION: There is evidence to support pathogen-specific, highly bioavailable oral antibiotic therapy as an appropriate choice after resection arthroplasty in a two-stage treatment of periprosthetic joint infections (PJIs) after an initial IV antibiotic period of at least 5-7 days.
LEVEL OF EVIDENCE: Limited
DELEGATE VOTE: Agree: 83%, Disagree: 14%, Abstain: 3% (Super Majority, Strong Consensus)

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