When should rifampin be added to the regimen of antibiotics for management of patients with periprosthetic joint infections (PJIs) undergoing surgical treatment?

Authors: Katherine Belden, Werner Zimmerli, Christian Lausmann, Mustafa Citak, Akos Zahar
RECOMMENDATION: Rifampin should be considered in the treatment of staphylococcal PJIs in patients managed surgically with debridement, antibiotics and implant retention (DAIR) or single-stage exchange where activity against biofi lm is required. Rifampin should only be used in
combination therapies, with the best reported combination appearing to be with a fl uoroquinolone.
LEVEL OF EVIDENCE: Moderate
DELEGATE VOTE: Agree: 96%, Disagree: 2%, Abstain: 2% (Unanimous, Strongest Consensus)

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